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1 (one, unit, unity) is a number, numeral, and glyph. It is the first and smallest positive integer of the infinite sequence of natural numbers. This fundamental property has led to its unique uses in other fields, ranging from science to sports, where it commonly denotes the first, leading, or top thing in a group. 1 is the unit of counting or measurement, a determiner for singular nouns, and a gender-neutral pronoun. Historically, the representation of 1 evolved from ancient Sumerian and Babylonian symbols to the modern Arabic numeral.

In mathematics, 1 is the multiplicative identity, meaning that any number multiplied by 1 equals the same number. 1 is by convention not considered a prime number. In digital technology, 1 represents the "on" state in binary code, the foundation of computing. Philosophically, 1 symbolizes the ultimate reality or source of existence in various traditions.

Fifteen or 15 may refer to:

• 15 (number)
• one of the years 15 BC, AD 15, 1915, 2015

Sixteen or 16 may refer to:

• 16 (number)
• one of the years 16 BC, AD 16, 1916, 2016

Year 300 (CCC) was a leap year starting on Monday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Constantius and Valerius (or, less frequently, year 1053 Ab urbe condita). The denomination 300 for this year has been used since the early Middle Ages / Medieval period, when the Latin language term / abbreviation "Anno Domini" ("In the year of Our Lord") for the calendar era became the prevalent universal / worldwide method for naming and numbering years. First beginning in Europe at the end of the Roman Empire (after the split of the Western Roman Empire and Eastern Roman Empire (later Byzantine Empire) in the early Middle Ages / Medieval period.

Then the Christian-oriented dating system then spreading west across the Atlantic Ocean with the Western European explorers and religious faith to the continents of the Americas of the Western Hemisphere, then through the simultaneous movement of the various Christian churches, and Europeans along sea trading routes with the military / political / economic / social influences of Colonialism / Imperialism spread worldwide to Africa, Asia and Australia / Oceania.

Year 400 (CD) was a leap year starting on Sunday (link will display the full calendar) of the Julian calendar. In the Roman Empire, it was known as the Year of the Consulship of Stilicho and Aurelianus (or, less frequently, year 1153 Ab urbe condita). The denomination 400 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.

An allergen is an otherwise harmless substance that triggers an allergic reaction in sensitive individuals by stimulating an immune response.

In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses. Most humans mount significant Immunoglobulin E responses only as a defense against parasitic infections. However, some individuals may respond to many common environmental antigens. This hereditary predisposition is called atopy. In atopic individuals, non-parasitic antigens stimulate inappropriate IgE production, leading to type I hypersensitivity.

Sensitivities vary widely from one person (or from one animal) to another. A very broad range of substances can be allergens to sensitive individuals.

A design is the concept of or proposal for an object, process, or system. The word design refers to something that is or has been intentionally created by a thinking agent, and is sometimes used to refer to the inherent nature of something – its design. The verb to design expresses the process of developing a design. In some cases, the direct construction of an object without an explicit prior plan may also be considered to be a design (such as in arts and crafts). A design is expected to have a purpose within a certain context, usually having to satisfy certain goals and constraints and to take into account aesthetic, functional, economic, environmental, or socio-political considerations. Traditional examples of designs include architectural and engineering drawings, circuit diagrams, sewing patterns, and less tangible artefacts such as business process models.

The drum is a member of the percussion group of musical instruments. In the Hornbostel-Sachs classification system, it is a membranophone. Drums consist of at least one membrane, called a drumhead or drum skin, that is stretched over a shell and struck, either directly with the player's hands, or with a percussion mallet, to produce sound. There is usually a resonant head on the underside of the drum. Other techniques have been used to cause drums to make sound, such as the thumb roll. Drums are the world's oldest and most ubiquitous musical instruments, and the basic design has remained virtually unchanged for thousands of years.

Drums may be played individually, with the player using a single drum, and some drums such as the djembe are almost always played in this way. Others are normally played in a set of two or more, all played by one player, such as bongo drums and timpani. A number of different drums together with cymbals form the basic modern drum kit.