Advanced Clinicals Collagen Skin Rescue Lotion, 16 oz

Sixteen or 16 may refer to:

• 16 (number), the natural number following 15 and preceding 17
• one of the years 16 BC, AD 16, 1916, 2016

Collagen () is the main structural protein in the extracellular matrix of a body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals. 25% to 35% of a mammalian body's protein content is collagen. Amino acids are bound together to form a triple helix of elongated fibril known as a collagen helix. The collagen helix is mostly found in connective tissue such as cartilage, bones, tendons, ligaments, and skin. Vitamin C is vital for collagen synthesis, while Vitamin E improves its production.

Depending upon the degree of mineralization, collagen tissues may be rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and accounts for 6% of the weight to skeletal muscle. The fibroblast is the most common cell creating collagen in a body. Gelatin, which is used in food and industry, is collagen that was irreversibly hydrolyzed using heat, basic solutions, or weak acids.

Lotion is a low-viscosity topical preparation intended for application to the skin. By contrast, creams and gels have higher viscosity, typically due to lower water content. Lotions are applied to external skin with bare hands, a brush, a clean cloth, or cotton wool.

While a lotion may be used as a medicine delivery system, many lotions, especially hand lotions and body lotions and lotion for allergies are meant instead to simply smooth, moisturize, soften and, sometimes, perfume the skin.

Some skincare products, such as sunscreen and moisturizer, may be available in multiple formats, such as lotions, gels, creams, or sprays.

Rescue comprises responsive operations that usually involve the saving of life, removal from danger, liberation from restraint, or the urgent treatment of injuries after an incident. It may be facilitated by a range of tools and equipment necessary to deal with the specific circumstances.

Rescues may be necessary in a wide range of circumstances and environments, and specialised procedures have been developed for many of these. A rescue may also be performed on an ad hoc basis by the people who are available on site, using equipment available on site or assembled from available materials, particularly when the rescue is urgent or it is unlikely that specialist assistance will be available within a reasonable time. First aid medical attention is often closely associated with rescue, and may be a necessary part of a rescue.

Equipment used might include search and rescue dogs, mounted search and rescue horses, helicopters, the "jaws of life", and other hydraulic cutting and spreading tools used to extricate occupants from wrecked vehicles. Rescue operations may be supported by rescue vehicles operated by rescue squads.

Searches are often associated with rescues when persons are missing and likely to be in danger.

Body recovery is also closely associated with rescue operations, and may be subject to different legal constraints. Occupational safety and health legislation may be waived for rescue operations where there is a realistic probability of saving a life, but not for body recovery.

Interspecies rescue can occur when people rescue animals, when animals are part of a rescue team, and less often, when animals rescue people on their own initiative.

Self-rescue is the process of getting out of an emergency by one's own efforts as an individual or a group.

Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation.

Other animal coverings, such as the arthropod exoskeleton, have different developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin cutis 'skin'). In mammals, the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue and guards the underlying muscles, bones, ligaments, and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. Skin (including cutaneous and subcutaneous tissues) plays crucial roles in formation, structure, and function of extraskeletal apparatus such as horns of bovids (e.g., cattle) and rhinos, cervids' antlers, giraffids' ossicones, armadillos' osteoderm, and os penis/os clitoris.

All mammals have some hair on their skin, even marine mammals like whales, dolphins, and porpoises that appear to be hairless. The skin interfaces with the environment and is the first line of defense from external factors. For example, the skin plays a key role in protecting the body against pathogens and excessive water loss. Its other functions are insulation, temperature regulation, sensation, and the production of vitamin D folates. Severely damaged skin may heal by forming scar tissue. This is sometimes discoloured and depigmented. The thickness of skin also varies from location to location on an organism. In humans, for example, the skin located under the eyes and around the eyelids is the thinnest skin on the body at 0.5 mm thick and is one of the first areas to show signs of aging such as "crows feet" and wrinkles. The skin on the palms and the soles of the feet is the thickest skin on the body at 4 mm thick. The speed and quality of wound healing in skin is promoted by estrogen.

Fur is dense hair. Primarily, fur augments the insulation the skin provides but can also serve as a secondary sexual characteristic or as camouflage. On some animals, the skin is very hard and thick and can be processed to create leather. Reptiles and most fish have hard protective scales on their skin for protection, and birds have hard feathers, all made of tough beta-keratins. Amphibian skin is not a strong barrier, especially regarding the passage of chemicals via skin, and is often subject to osmosis and diffusive forces. For example, a frog sitting in an anesthetic solution would be sedated quickly as the chemical diffuses through its skin. Amphibian skin plays key roles in everyday survival and their ability to exploit a wide range of habitats and ecological conditions.

On 11 January 2024, biologists reported the discovery of the oldest known skin, fossilized about 289 million years ago, and possibly the skin from an ancient reptile.